- Specifications
Product Description
Mouse monoclonal antibody raised against partial recombinant CD80.
Immunogen
Recombinant Fc fusion protein corresponding to extracellular region of human CD80.
Host
Mouse
Theoretical MW (kDa)
60
Reactivity
Human
Specificity
This antibody reacts with CD80 (B7-1), a 60 KDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Form
Liquid
Conjugation
PerCP
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Flow Cytometry
- Gene Info — CD80
Entrez GeneID
941Gene Name
CD80
Gene Alias
CD28LG, CD28LG1, LAB7
Gene Description
CD80 molecule
Omim ID
112203Gene Ontology
HyperlinkGene Summary
The B-lymphocyte activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.[supplied by OMIM
Other Designations
B-lymphocyte activation antigen B7|CD80 antigen|CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)|costimulatory factor CD80|costimulatory molecule variant IgV-CD80
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Suppression of colon inflammation by CD80 blockade: evaluation in two murine models of inflammatory bowel disease.
Eri R, Kodumudi KN, Summerlin DJ, Srinivasan M.
Inflammatory Bowel Diseases 2008 Apr; 14(4):458.
- CD86 has sustained costimulatory effects on CD8 T cells.
Thomas IJ, Petrich de Marquesini LG, Ravanan R, Smith RM, Guerder S, Flavell RA, Wraith DC, Wen L, Wong FS.
Journal of Immunology 2007 Nov; 179(9):5936.
- Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment.
Campioni D, Moretti S, Ferrari L, Punturieri M, Castoldi GL, Lanza F.
Haematologica 2006 Mar; 91(3):364.
- Suppression of colon inflammation by CD80 blockade: evaluation in two murine models of inflammatory bowel disease.
CD80 monoclonal antibody, clone MEM-233 (PerCP)
Cat# MAB5129
Size : 100Reactions
Brand : Abnova
Contact local distributor :
Phone : +1 850 650 7790