Aristolochic acid B [475-80-9]
Cat# NB-64-38345-25mg
Size : 25mg
Brand : Neo Biotech
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Aristolochic acid B (Synonyms: Aristolochic Acid II)
Catalog No. T7031 Copy Product Info
Purity: 99.99%
Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.
Aristolochic acid B
Copy Product InfoSynonyms Aristolochic Acid II
Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.
Cas No. 475-80-9
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Purity:99.99%
Appearance:Solid
Color:Yellow
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Product Introduction
Aristolochic acid B AI Summary
Aristolochic acid B exhibits bioactivity by inhibiting CDK2, although it does so with an IC50 value greater than 20000 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I. |
| In vivo | METHODS: Aristolochic acid B (Aristolochic Acid II) (5 mg/kg, intragastrically, 5 times a week for 6 weeks) was compared for DNA adduct formation and mutagenicity in the kidneys of gptδ transgenic mice. RESULTS Aristolochic acid B (Aristolochic Acid II) induced mutations at a frequency nearly two-fold higher than that induced by aristolochic acid I, showing a higher carcinogenic risk in vivo than aristolochic acid I, which may be at least partly the result of its elevated levels in the kidneys and plasma. [1] |
| Synonyms | Aristolochic Acid II |
| Molecular Weight | 311.25 |
| Formula | C16H9NO6 |
| Cas No. | 475-80-9 |
| Smiles | OC(=O)c1cc2OCOc2c2c3ccccc3cc([N+]([O-])=O)c12 |
| Relative Density. | 1.61 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (32.13 mM), Sonication is recommended.  Chloroform: Soluble | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.21 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||