| Short Description : | Rabbit polyclonal antibody anti-SLC5A1 (603-623) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Host: | Rabbit |
| Reactivity: | Human/Monkey/Mouse/Rat/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Biotin |
| Concentration: | 0.55 µg/µl |
| Purification: | Affinity Purified |
| Dilution Range: | WB: 1:500-1:1, 000DB: 1:4, 000ELISA: 1:4, 000IP: 1:200IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
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| Immunogen: | Synthetic peptide corresponding to amino acids 603-623 of Human SGLT1. |
| Immunogen Region: | 603-623 |
| Tissue Specificity | Expressed in intestine. Expressed in endometrial cells. |
| Post Translational Modifications | N-glycosylation is not necessary for the cotransporter function. |
| Function | Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. |
| Protein Name | Sodium/Glucose Cotransporter 1Na(+/Glucose Cotransporter 1High Affinity Sodium-Glucose CotransporterSolute Carrier Family 5 Member 1 |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Glucose Cotransporter 1 antibodyAnti-Na(+/Glucose Cotransporter 1 antibodyAnti-High Affinity Sodium-Glucose Cotransporter antibodyAnti-Solute Carrier Family 5 Member 1 antibodyAnti-SLC5A1 antibodyAnti-NAGT antibodyAnti-SGLT1 antibody |
Information sourced from Uniprot.org