| Short Description : | Rabbit polyclonal antibody anti-NAMPT (200-300) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications: | ELISA/IHC/IP/WB |
| Host: | Rabbit |
| Reactivity: | Chicken/Human/Mouse/Pig/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Biotin |
| Concentration: | 0.68-0.70 µg/µl |
| Purification: | Affinity Purified |
| Dilution Range: | WB: 1:500DB: 1:4, 000ELISA: 1:4, 000IP: 1:150IHC: 1:50-1:100 |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
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| Immunogen: | N-epitope synthetic peptide taken within amino acid region 200-300 on human Visfatin protein. |
| Immunogen Region: | 200-300 |
| Tissue Specificity | Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues. |
| Function | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. |
| Protein Name | Nicotinamide PhosphoribosyltransferaseNamprtaseNamptPre-B-Cell Colony-Enhancing Factor 1Pre-B Cell-Enhancing FactorVisfatin |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmSecretedUnder Non-Inflammatory ConditionsVisfatin Predominantly Exhibits A Granular Pattern Within The NucleusSecreted By Endothelial Cells Upon Il-1beta StimulationAbundantly Secreted In MilkReaching 100-Fold Higher Concentrations Compared To Maternal Serum |
| Alternative Antibody Names | Anti-Nicotinamide Phosphoribosyltransferase antibodyAnti-Namprtase antibodyAnti-Nampt antibodyAnti-Pre-B-Cell Colony-Enhancing Factor 1 antibodyAnti-Pre-B Cell-Enhancing Factor antibodyAnti-Visfatin antibodyAnti-NAMPT antibodyAnti-PBEF antibodyAnti-PBEF1 antibody |
Information sourced from Uniprot.org