Anti-HSP60 (Mab11-13) Antibody
Cat# OAED00191
Size : 50ug
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
Anti-HSP60 (Mab11-13) Antibody (OAED00191)
| Datasheets/Manuals | Printable datasheet for Anti-HSP60 (Mab11-13) Antibody (OAED00191) |
|---|
| Predicted Species Reactivity | Bovine|Dog|Dolphin|Drosophila|Fish|Guinea Pig|Hamster|Human|Monkey|Mosquito|Mouse|Porcine|Rabbit|Rat|Snake |
|---|---|
| Clonality | Monoclonal |
| Clone | Mab-11-13 |
| Isotype | IgG2a |
| Host | Mouse |
| Application | Flow cytometry|Immunofluorescence|Western blot |
| Reconstitution and Storage | Long Term Storage : -20C |
| Immunogen | Recombinant human Hsp60. |
| Specificity | Recognizes human, mouse, rat, bovine, dog, dolphin, Drosophila, fish, guinea pig, hamster, mosquito, monkey, pig, rabbit and snake HSP60. Detects a band of ~60kDa by Western blot. |
| Formulation | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Purity | Protein G affinity purified. |
| Application Info | Flow Cytometry (10μg/ml) Immunofluorescence Immunohistochemistry (paraffin sections) Western Blot (1:1000, colorimetric) Optimal conditions must be determined individually for each application. |
| Gene Symbol | HSPD1 |
|---|---|
| Gene Full Name | heat shock protein family D (Hsp60) member 1 |
| Alias Symbols | 60 kDa chaperonin;60 kDa heat shock protein, mitochondrial;chaperonin 60;CPN60;epididymis secretory sperm binding protein;GROEL;heat shock 60kDa protein 1 (chaperonin);Heat shock protein 60;heat shock protein 65;HLD4;HSP60;HSP-60;HSP65;HuCHA60;mitochondrial matrix protein P1;P60 lymphocyte protein;short heat shock protein 60 Hsp60s1;SPG13. |
| NCBI Gene Id | 3329 |
| Protein Name | 60 kDa heat shock protein, mitochondrial |
| Description of Target | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). |
| Uniprot ID | P10809 |
