| Short Description : | Rabbit polyclonal DLG1 (1-190) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | |
| Gene ID: | |
| Uniprot ID: | |
| Immunogen Region: | 1-190 |
| Immunogen Sequence: | MPVRKQDTQRALHLLEEYRS KLSQTEDRQLRSSIERVINI FQSNLFQALIDIQEFYEVTL LDNPKCIDRSKPSEPIQPVN TWEISSLPSSTVTSETLPSS LSPSVEKYRYQDEDTPPQEH ISPQITNEVIGPELVHVSEK NLSEIENVHGFVSHSHISPI KPTEAVLPSPPTVPVIPVLP VPAENTVILP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human DLG1 (NP_004078.2). |
| Tissue Specificity | Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Expressed in the brain (at protein level). Widely expressed, with isoforms displaying different expression profiles. |
| Post Translational Modifications | Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A. Ubiquitinated.by MARCHF2 which results in its degradation. |
| Function | Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion. May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane. |
| Protein Name | Disks Large Homolog 1Synapse-Associated Protein 97Sap-97Sap97Hdlg |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembranePostsynaptic DensitySynapseSarcolemmaApical Cell MembraneCell JunctionCytoplasmColocalizes With Epb41 At Regions Of Intercellular ContactsBasolateral In Epithelial CellsMay Also Associate With Endoplasmic Reticulum MembranesMainly Found In Neurons SomaModerately Found At Postsynaptic Densities |
| Alternative Antibody Names | Anti-Disks Large Homolog 1 antibodyAnti-Synapse-Associated Protein 97 antibodyAnti-Sap-97 antibodyAnti-Sap97 antibodyAnti-Hdlg antibodyAnti-DLG1 antibody |
Information sourced from Uniprot.org