| Short Description : | Mouse monoclonal anti-B-Cell Differentiation antigen Cd72 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 3F3 |
| Isotype: | IgG2bk |
| Conjugation: | FITC |
| Concentration: | 5 Mu L/Tests |
| Purification: | Affinity purified |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction: | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
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| Tissue Specificity | Pre-B-cells and B-cells but not terminally differentiated plasma cells. |
| Post Translational Modifications | Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1. |
| Function | Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis. |
| Protein Name | B-Cell Differentiation Antigen Cd72Lyb-2Cd Antigen Cd72 |
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| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-B-Cell Differentiation Antigen Cd72 antibodyAnti-Lyb-2 antibodyAnti-Cd Antigen Cd72 antibodyAnti-CD72 antibody |
Information sourced from Uniprot.org