| Short Description : | Rat monoclonal anti-Transferrin Receptor Protein 1 for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Rat |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R17 217.1.3/TIB-219 |
| Isotype: | IgG2ak |
| Conjugation: | AF647 |
| Concentration: | 5 Mu L/Test |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction: | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
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| Post Translational Modifications | Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation. Stearoylation does not affect iron uptake. N- and O-glycosylated, phosphorylated and palmitoylated. |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production. |
| Protein Name | Transferrin Receptor Protein 1TrTfrTfr1TrfrCd Antigen Cd71 |
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| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMelanosome |
| Alternative Antibody Names | Anti-Transferrin Receptor Protein 1 antibodyAnti-Tr antibodyAnti-Tfr antibodyAnti-Tfr1 antibodyAnti-Trfr antibodyAnti-Cd Antigen Cd71 antibodyAnti-Tfrc antibodyAnti-Trfr antibody |
Information sourced from Uniprot.org