| |
| Gene : | ITGA2 |
| Gene ID : | 3673 |
| Uniprot ID : | P17301 |
| Alternative Name : | ITGA2, CD49B |
| Immunogen Information : | Human platelets |
CD49b / Integrin alpha 2 (ITGA2; alpha 2 subunit of VLA-2) heterodimerizes with CD29 to form the VLA-2 integrin alpha2/beta1 complex, which serves as a receptor for type I collagen, laminin, and E-cadherin. It also acts as a receptor for echovirus. Expressed on platelets, activated lymphocytes, monocytes, fibroblasts, epitelial and endothelial cells, CD49b mediates adhesion of these cells to the extracellular matrix. This interaction supports e.g. T cell proliferation and cytokine production, or wound healing. Defect in CD49b is associated with bleeding disorder platelet-type 9. Antibodies against CD49b are found in several immune disorders, including neonatal alloimmune thrombocytopenia.
| Subcellular location: | Membrane |
| BioGrid: | 109880. 31 interactions. |
| There are currently no product reviews
|
