| Short Description : | Armenian Hamster monoclonal anti-C-X-C chemokine receptor type 3 for use in FC in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Armenian Hamster |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | CXCR3-173 |
| Isotype: | IgG |
| Conjugation: | PE/Cyanine5 |
| Concentration: | 0.2 mg/mL |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction: | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
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| Tissue Specificity | Expresses in lymphoid organs and Th1 cells. |
| Post Translational Modifications | Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding. N-glycosylated. |
| Function | Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. |
| Protein Name | C-X-C Chemokine Receptor Type 3Cxc-R3Cxcr-3Interferon-Inducible Protein 10 ReceptorIp-10 ReceptorCd Antigen Cd183 |
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| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-X-C Chemokine Receptor Type 3 antibodyAnti-Cxc-R3 antibodyAnti-Cxcr-3 antibodyAnti-Interferon-Inducible Protein 10 Receptor antibodyAnti-Ip-10 Receptor antibodyAnti-Cd Antigen Cd183 antibodyAnti-Cxcr3 antibodyAnti-Cmkar3 antibody |
Information sourced from Uniprot.org