alpha-D-glucose [492-62-6]

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Cat# NB-64-29112-500mg

Size : 500mg

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Phone : +1 850 650 7790

Brand : Neo Biotech

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Phone : +1 850 650 7790

alpha-D-glucose (Synonyms: α-D-Glucose, α-Dextrose, alpha-Glucose)

Catalog No. T4884 Copy Product Info

Purity: 99.87%

alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

alpha-D-glucose

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Synonyms α-D-Glucose, α-Dextrose, alpha-Glucose

Cas No. 492-62-6

Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

alpha-D-glucose AI Summary

alpha-D-glucose shows a broad spectrum of bioactivities. It has very low partition coefficients, with logP values below -3, indicating a preference for partitioning into water over dodecane. In terms of its biochemical interactions, alpha-D-glucose demonstrates competitive inhibition of rabbit muscle glycogen phosphorylase b with a Ki value of 1,700,000.0 nM and has additional inhibitory effects on liver glycogen phosphorylase a, with Ki values ranging up to 4,900,000.0 nM. The compound also promotes [1-3H]-2-deoxy-D-glucose uptake in 3T3 L1 adipocytes, with observed activity of 34.0 Bq. In antiviral assays, alpha-D-glucose inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at a 10 uM concentration after 48 hours with an inhibition rate of 32.8%, though other assays showed a lower inhibition rate of 12.57% on SARS-CoV-2 3CL-Pro protease activity at a 20 µM concentration. Additionally, it interacts with calf thymus DNA, displacing EtBr with a C50 of 390.0 uM, and significantly increases the melting temperature of the DNA-ligand complex by 10.3°C. Furthermore, it shows inhibitory activities against human HDAC6, with inhibition percentages of -23.98% and -14.18% using different peptide substrates. These diverse bioactivities suggest potential applications in enzyme inhibition, antiviral therapy, and modulation of DNA-protein interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Synonyms	α-D-Glucose, α-Dextrose, alpha-Glucose

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	492-62-6
Smiles	C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)O1
Relative Density.	1.544g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (249.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.