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> ACTH (1-39) (Human)

ACTH (1-39) (Human)

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Cat# 254539-1mg

Size : 1mg

Brand : US Biological

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Phone : +1 850 650 7790

254539 ACTH (1-39) (Human)

Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.

Amino Acid Sequence:
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

Storage and Stability:
Lyophilized powder may be stored at 4°C for short-term only. Stable for 6 months after receipt at -20°C. Reconstitute (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Purity: ≥95%|Form: White, lyophilized powder||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a lyophilized powder
Purity
≥95%
References
1. Bertolini et al (2009) Brain effects of melanocortins. Pharmacol.Res. 59 13. PMID: 18996199. 2. Iwen et al (2008) Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes. J.Endocrinol. 196 465. PMID: 18310442. 3. Kapas et al (1996) Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137 3291. PMID: 8754753.