SARS-CoV-2 - Ruxolitinib - Therapeutic Candidates

SARS-CoV-2 - Ruxolitinib - Therapeutic Candidates


Ruxolitinib, whose commercial name is Jakavi, is a tyrosine kinase inhibitor and more specifically Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2) which are JAK-targeting tyrosine kinases.  Ruxolitinib is used for the treatment of certain myeloproliferative syndromes such as myelofibrosis. It is also used for the treatment of Vaquez disease (essential polyglobulia or polycythemia vera or rubra), characterized by polyglobulia and an increase in total blood cell volume.
The Novartis group, which markets Jakavi, began studying the effects of this drug on Covid-19 caused by SARS-CoV-2. The purpose of this clinical study is to determine whether ruxolitinib could mitigate the potential complications of Covid-19 and involves patients with Covid-19-related cytokine shock. This Phase III clinical study is based on the fact that the JAK-STAT pathway is fundamental to many biological processes related to immunity and inflammation, including the mobilization of a cytokine response.

Cat#
Description
Size
Price Excl. VAT
HY-50858-1mL
 10mM/1mL 
HY-50859-5mg
 5mg 
HY-50858-5mg
 5mg 
HY-50856A-5mg
 5mg 
HY-50856-S
 0,5-1mg 
HY-50856A-1mg
 1mg 
HY-50859-50mg
 50mg 
HY-50856-1mL
 10mM/1mL 
HY-50858-S
 0,5-1mg 
HY-50859-100mg
 100mg 
HY-50858-50mg
 50mg 
HY-50856-50mg
 50mg 
HY-50856A-1mL
 10mM/1mL 
HY-50858-1g
 1g 
HY-50856-5mg
 5mg 
HY-50858-100mg
 100mg 
HY-50856-100mg
 100mg 
HY-50858-500mg
 500mg 
HY-50856-1g
 1g 
HY-50858-10mg
 10mg 
HY-50856-10mg
 10mg 
HY-50858-200mg
 200mg 
HY-50856-200mg
 200mg 
HY-50856-500mg
 500mg 
HY-50859-10mg
 10mg 
R702015-25mg
 25mg 
SKP3276-10
 10mg 
SKP3276-100
 100mg 
SKP3276-25
 25mg 
R701855-10mg
 10mg 
SKP3276-5
 5mg 
R701855-2.5mg
 2.5mg 
SKP3276-50
 50mg 
R701855-25mg
 25mg 
R701997-25mg
 25mg 
R701997-50mg
 50mg 
R701998-1mg
 1mg 
R701998-2.5mg
 2.5mg 
2139-100
 100mg 
R701998-25mg
 25mg 
R702010-10mg
 10mg 
R702010-1mg
 1mg 
SY-INCB018424-1mg
 1 mg 
R702010-5mg
 5mg 
SY-INCB018424-10mg
 10 mg 
R702015-10mg
 10mg 
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