SARS-CoV-2 - Losartan - Therapeutic Candidates

SARS-CoV-2 - Losartan - Therapeutic Candidates


Losartan is an angiotensin II receptor antagonist, so it is a hypertensive agent. Angiotensin II is naturally present in the body but it can cause constriction of the blood vessels which increases blood pressure, hypertension. Losartan is therefore used to lower mild to moderate forms of hypertension.
Various studies have shown that the ACE2 protein could be the gateway for the SARS-CoV-2 virus to enter the human body and therefore act as a receptor for SARS-CoV-2 which is the cause of Covid-19. Angiotensin converting enzyme II (ACE2) is a protein (carboxypeptidase) homologous to the angiotensin converting enzyme (historically called ACE, which should now be renamed ACE1). ACE2 negatively regulates the renin-angiotensin system and acts as an angiotensin II clearance protein by converting it to angiotensin which is an active peptide but has properties opposite to those of angiotensin II. A study conducted in mice showed a decrease in the level of ACE2 in mouse lungs after injection of CoV-2-CoV-SARS as well as a deterioration of respiratory functions. Administration of losartan would have improved respiratory function in these same mice by restoring normal levels of ACE2.

Cat#
Description
Size
Price Excl. VAT
HY-17512-S
 0,5-1mg 
HY-17512-1mL
 10mM/1mL 
HY-17512A-S
 0,5-1mg 
HY-17512A-1mL
 10mM/1mL 
HY-17512A-1g
 1g 
HY-17512-1g
 1g 
HY-17512S-1mg
 1mg 
HY-17512S-5mg
 5mg 
HY-12765S-10mg
 10mg 
HY-12765S-1mg
 1mg 
HY-12765S-5mg
 5mg 
HY-17512A-5g
 5g 
HY-17512-5g
 5g 
022569-25mg
 25mg 
255705-50mg
 50mg 
281374-10g
 10g 
022570-1mg
 1mg 
022571-25mg
 25mg 
022572-10mg
 10mg 
L470497-0.5mg
 0.5mg 
L470497-5mg
 5mg 
L470530-100mg
 100mg 
Number of results per page : 10 50 250