SARS-CoV-2 - Leflunomide - Therapeutic Candidates

SARS-CoV-2 - Leflunomide - Therapeutic Candidates


Leflunomide is an immunosuppressant used as a disease-modifying drug for rheumatoid arthritis and psoriatic arthritis. Immunosuppressants are drugs that decrease the immune system and chronic inflammation of the joints. Leflunomide has an anti-rheumatic effect with a slow onset of action. It works by stabilizing the overactivity of immune system cells that cause inflammation of the joints. To do this, leflunomide inhibits the mitochondrial enzyme dihydroorotate dehydrogenase (DHOH) which plays a key role in the synthesis of uridine monophosphate (rUMP), necessary for the synthesis of DNA and RNA. 
A study to examine the tolerability of high doses of leflunomide in patients with COVID-19 who are not yet hospitalized, but who have risk factors for disease progression and complications, has begun. In vitro studies have shown the antiviral effects of leflunomide against CoV-2-SARS. The hypothesis of this study is that targeting high-risk patients earlier in disease progression and a higher dose of leflunomide are necessary to see an improvement in disease outcome with COVID-19.

Cat#
Description
Size
Price Excl. VAT
HY-B0083-500mg
 500mg 
HY-B0083-1mL
 10mM/1mL 
HY-B0083-S
 0,5-1mg 
HY-B0083-100mg
 100mg 
L-2372-10mg
 10 mg 
L-2372-50mg
 50 mg 
L322750-100mg
 100mg 
L322750-1g
 1g 
L322750-25mg
 25mg 
L322750-500mg
 500mg 
L322750-50g
 50g 
L322750-50mg
 50mg 
L322752-10mg
 10mg 
L322752-1mg
 1mg 
281217-10mg
 10mg 
281217-25mg
 25mg 
281217-50mg
 50mg 
L322765-50mg
 50mg 
A2852-1ml
 10 mM (in 1mL DMSO) 
271732-100mg
 100mg 
271732-25mg
 25mg 
271732-50mg
 50mg 
S1159-200mg
 200mg 
A2852-100mg
 100 mg 
453616-100mg
 100mg 
453616-50mg
 50mg 
453617-100mg
 100mg 
453617-25mg
 25mg 
10-2369-250mg
 250 mg 
10-2369-50mg
 50 mg 
1972-10
 10mg 
1972-50
 50mg 
A10521-10mM-D
 10mM*1mLinDMSO 
271732-10mg
 10mg 
VD-OEIA-0113-50mg
 50 mg 
VD-OEIA-0113-5mg
 5 mg 
A10521-100
 100mg 
A10521-500
 500mg 
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