SARS-CoV-2 - Isotretinoin - Therapeutic Candidates
Isotretinoin is a derivative of vitamin A that occurs naturally in the body and is produced by the liver, called retinoid. Isotretinoin is indicated in the treatment of acne and especially severe forms that are resistant to antibiotic treatment. Although the exact mechanism of isotretinoin is not well identified, it appears to be an anti-inflammatory effect of the dermis. Isotretinoin inhibits the proliferation of sebocytes and seems to promote their de-differentiation into keratinocytes. It therefore reduces the production of sebum, which is the essential substrate for the growth of Propionibacterium acnes, and thus decreases the colonization of the hair canal by this bacterium.
A recent study demonstrated that isotretinoin is a potential inhibitor of papain-like protease (PLpro), which is a protein encoded by the CoV-2-SARS genes and is considered one of the proteins that should be targeted in Covid-19 therapy. In addition, isotretinoin is thought to increase CD4 counts and significantly decrease viremia in HIV-positive patients with acne vulgaris.
Price Excl. VAT
10 mM (in 1mL DMSO)
1ml/10mM (In DMSO)