SARS-CoV-2 - Isotretinoin - Therapeutic Candidates

SARS-CoV-2 - Isotretinoin - Therapeutic Candidates


Isotretinoin is a derivative of vitamin A that occurs naturally in the body and is produced by the liver, called retinoid. Isotretinoin is indicated in the treatment of acne and especially severe forms that are resistant to antibiotic treatment. Although the exact mechanism of isotretinoin is not well identified, it appears to be an anti-inflammatory effect of the dermis. Isotretinoin inhibits the proliferation of sebocytes and seems to promote their de-differentiation into keratinocytes. It therefore reduces the production of sebum, which is the essential substrate for the growth of Propionibacterium acnes, and thus decreases the colonization of the hair canal by this bacterium.
A recent study demonstrated that isotretinoin is a potential inhibitor of papain-like protease (PLpro), which is a protein encoded by the CoV-2-SARS genes and is considered one of the proteins that should be targeted in Covid-19 therapy. In addition, isotretinoin is thought to increase CD4 counts and significantly decrease viremia in HIV-positive patients with acne vulgaris.

Cat#
Description
Size
Price Excl. VAT
HY-15127-500mg
 500mg 
HY-15127-S
 0,5-1mg 
HY-15127-100mg
 100mg 
A10485-250
 250mg 
A10485-500
 500mg 
A10485-1000
 1000mg 
A10485-2000
 2000mg 
A4330-100mg
 100 mg 
A4330-1ml
 10 mM (in 1mL DMSO) 
A10485-10mM-D
 10mM*1mLinDMSO 
M5715-100mg
 100 mg 
M5715-500mg
 500 mg 
S1611-200mg
 200mg 
S1611-100mg
 100mg 
255532-50mg
 50mg 
MBS575178-2mg
 2 mg 
MBS575178-10mg
 10 mg 
MBS575178-1ml
 1ml/10mM (In DMSO) 
MBS575178-50mg
 50 mg 
MBS575178-200mg
 200 mg