SARS-CoV-2 - Etoposide - Therapeutic Candidates

SARS-CoV-2 - Etoposide - Therapeutic Candidates


Etoposide is a topoisomerase II inhibitor. It is also available as etoposide phosphate. Etoposide inhibits the entry of tumor cells into mitosis, which is why it is used, in combination with other chemotherapy agents, for the treatment of certain cancers such as lung cancer, testicular cancer, certain lymph and leukemias, and glioblastoma.
Toposimerase II inhibitors such as etoposide have been shown to be effective in the treatment of cytokine storm caused by lymphohistiocytosis haemophagocytosis (LHH). These inhibitors have also been shown to suppress the replication of RNA viruses in vitro. The toxicity profile of topoisomerase II inhibitors in patients with LHH does not translate in severely ill patients because COVID-19 and LHH have fundamentally different causes of their respective cytokine storms: an over-stimulated innate immune response is the cause of cytokine storms in COVID-19 infection, while an over-stimulated adaptive immune response is the cause of cytokine storms in LHH. Etoposide could be used in combination with irinotecan a topisomerase I inhibitor for effective action against SARS-CoV-2 coronavirus.

Cat#
Description
Size
Price Excl. VAT
BV-1043-3
 100µl 
HY-13629-200mg
 200mg 
HY-13629-500mg
 500mg 
HY-13629-S
 0,5-1mg 
HY-13629-1mL
 10mM/1mL 
JM-1043-25MG
 25mg 
HY-13629-100mg
 100mg 
A1971-100mg
 100 mg 
T0132-100mg
 100mg 
T0132-200mg
 200mg 
T0132-500mg
 500mg 
E-2004-100mg
 100 mg 
T0132-1ml
 1 ml 10 mm in dmso 
E-2004-500mg
 500 mg 
449848-10mg
 10mg 
449848-1mg
 1mg 
TG4140
 0.25 ml 
A10373-10mM-D
 10mM*1mLinDMSO 
275911-100mg
 100mg 
275911-25mg
 25mg 
275911-50mg
 50mg 
S0132-100mg
 100mg 
293403-100mg
 100mg 
S0132-200mg
 200mg 
293403-25mg
 25mg 
S0132-500mg
 500mg 
293403-50mg
 50mg 
E933740-100mg
 100mg 
E933740-10mg
 10mg 
275390-1g
 1g 
E933745-10mg
 10mg 
275390-250mg
 250mg 
VD-Ant-0270-100mg
 100 mg 
E933745-1mg
 1mg 
275390-500mg
 500mg 
VD-Ant-0270-1g
 1 g 
E933750-100mg
 100mg 
E933750-1g
 1g 
E933750-250mg
 250mg 
E933750-2g
 2g 
E933750-500mg
 500mg 
E933750-50mg
 50mg 
E933755-250mg
 250mg 
abx076574-100mg
 100mg 
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