SARS-CoV-2 - Colchicine - Therapeutic Candidates

SARS-CoV-2 - Colchicine - Therapeutic Candidates


Colchicine is an anti-inflammatory drug used in rheumatology and particularly for the treatment of gouty arthritis or gout. Colchicine is also used in the treatment of other pathologies such as chronic atrophic polychondritis or acute pericarditis after failure of aspirin. 
Studies have shown that SARS-CoVs activate NLRP3 inflammasomes, intracytoplasmic particles that stimulate the release of pro-inflammatory cytokines. In particular, colchicine is believed to inhibit the assembly of the NLRP3 inflammasome and thus the release of cytokines, in particular interleukin-1 beta and interleukin-6. Colchicine is believed to inhibit certain functions of the inflammasome, a component of the immune system that plays a role in triggering cytokine shock and the associated inflammatory cascade. Targeting the inflammatory response with colchicine may therefore reduce complications related to Covid-19 in adults at risk or with signs of inflammatory storm. Three studies are currently underway to investigate the effects of colchicine on Covid-19, the largest, called COLCORONA, involves 6000 patients in Canada.

Cat#
Description
Size
Price Excl. VAT
271400-100mg
 100mg 
271400-25mg
 25mg 
271400-50mg
 50mg 
271401-250mg
 250mg 
271401-500mg
 500mg 
C2026-25ML
 25ML 
M3460-100mg
 100 mg 
271400-10mg
 10mg 
M3460-10mM
 10 mM/1mL 
271400-5mg
 5mg 
271401-100mg
 100mg 
271401-25mg
 25mg 
271401-50mg
 50mg 
417393-1mg
 1mg 
417393-500ug
 500ug 
290128-1g
 1g 
290128-250mg
 250mg 
290128-500mg
 500mg 
268672-250mg
 250mg 
268672-500mg
 500mg 
268673-10mg
 10mg 
268673-25mg
 25mg 
268673-50mg
 50mg 
D230465-100mg
 100mg 
D230465-10mg
 10mg 
T353000-100mg
 100mg 
D230465-250mg
 250mg 
T353000-1g
 1g 
D230465-500mg
 500mg 
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