SARS-CoV-2 - Colchicine - Therapeutic Candidates

SARS-CoV-2 - Colchicine - Therapeutic Candidates


Colchicine is an anti-inflammatory drug used in rheumatology and particularly for the treatment of gouty arthritis or gout. Colchicine is also used in the treatment of other pathologies such as chronic atrophic polychondritis or acute pericarditis after failure of aspirin. 
Studies have shown that SARS-CoVs activate NLRP3 inflammasomes, intracytoplasmic particles that stimulate the release of pro-inflammatory cytokines. In particular, colchicine is believed to inhibit the assembly of the NLRP3 inflammasome and thus the release of cytokines, in particular interleukin-1 beta and interleukin-6. Colchicine is believed to inhibit certain functions of the inflammasome, a component of the immune system that plays a role in triggering cytokine shock and the associated inflammatory cascade. Targeting the inflammatory response with colchicine may therefore reduce complications related to Covid-19 in adults at risk or with signs of inflammatory storm. Three studies are currently underway to investigate the effects of colchicine on Covid-19, the largest, called COLCORONA, involves 6000 patients in Canada.

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Price Bef. VAT
orb1297034-25mg
 25mg 
orb1217691-5mg
 5mg 
orb1297034-10mg
 10mg 
C7507-03-1mg
 1mg 
021742-100mg
 100mg 
290128-500mg
 500mg 
045335-25mg
 25mg 
290128-1g
 1g 
290128-50mg
 50mg 
007024-2.5mg
 2.5mg 
290128-100mg
 100mg 
045335-5mg
 5mg 
290128-250mg
 250mg 
015712-10mg
 10mg 
469803-2.5mg
 2.5mg 
469803-25mg
 25mg 
271240-25mg
 25mg 
271240-1mg
 1mg 
271240-10mg
 10mg 
271241-250mg
 250mg