Lysozyme (muramidase) is a well-characterized antimicrobial enzyme involved in innate immunity and is widely expressed in cells of myeloid and monocytic lineage. Its detection by immunohistochemistry (IHC) is commonly used in hematopathology to support lineage assignment and the characterization of hematolymphoid neoplasms.
Biological Significance of LYSOZYME
- Lysozyme is a hydrolytic enzyme that contributes to bacterial cell wall degradation and innate host defense.
- It is physiologically expressed in neutrophils, monocytes, macrophages, and related histiocytic cells.
- Its expression reflects myeloid differentiation and is associated with cells involved in phagocytic and antimicrobial functions.
Diagnostic Utility in Hematopathology
- Lysozyme IHC is used as a myeloid/monocytic marker in tissue sections, particularly formalin-fixed, paraffin-embedded (FFPE) specimens.
- It assists in identifying:
- Myeloid leukemias with monocytic differentiation
- Histiocytic and macrophage-rich lesions
- Tumors with suspected monocytic lineage
- It is typically used in combination with other immunomarkers (e.g., CD markers) and morphologic evaluation to improve diagnostic accuracy in lymphoma and leukemia classification.
Key Features of LYSOZYME CE/IVD Antibodies
- Validated for immunohistochemical detection in FFPE tissues
- Intended for in vitro diagnostic (IVD) use under CE marking, supporting clinical laboratory workflows.
- Designed to detect cytoplasmic lysozyme expression in myeloid/monocytic cells.
- Used as part of diagnostic panels in hematopathology alongside morphology and complementary immunostains.
- Provide reproducible staining suitable for routine pathology practice.
