Size : 1mg
Phone : +1 850 650 7790
Synonyms: 9,11-Methanoepoxy PGH2
| Description | U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion. |
| In vitro | U-46619 (5 μg/kg; i.v.) significantly increased blood pressure in male spontaneously hypertensive rats.[3] The effect of Esmolol on blood pressure in male spontaneously hypertensive rats was shown in the study. [3] |
| In vivo | U-46619 (5 μg/kg; i.v.) significantly increased blood pressure in male spontaneously hypertensive rats.[3] The effect of Esmolol on blood pressure in male spontaneously hypertensive rats was shown in the study. [3] |
| Synonyms | 9,11-Methanoepoxy PGH2 |
| Molecular Weight | 350.49 |
| Formula | C21H34O4 |
| Cas No. | 56985-40-1 |
| Smiles | C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@]2(C[C@@]1(CO2)22)22 |
| Relative Density. | 1.092g/cm3 |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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