Type I Collagen Antibody
Cat# OASB02738
Size : 0.2mg
Brand : Aviva Systems Biology
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Type I Collagen Antibody (OASB02738)
| Datasheets/Manuals | Printable datasheet for Type I Collagen Antibody (OASB02738) |
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| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Mouse, Rat, Bovine, Canine, Chicken, Chinchilla, Elephant, Feline, Guinea Pig, Hamster, Porcine, Rabbit, Sheep, Tree Shrew |
| Product Format | Liquid Borate buffered saline (pH 8.2) |
| Clonality | Polyclonal |
| Host | Goat |
| Conjugation | Unconjugated |
| Application | EM, FC, ICC, IHC-F, IHC-P, IP, WB |
| Reconstitution and Storage | Store at 2-8°C |
| Purification | Purified by affinity chromatography on type I collagen covalently linked to agarose. |
| Concentration | Varies by lot. See vial for concentration. |
| Specificity | Reacts with conformational determinants on type I collagen; cross-adsorbed against Collagen types II, III, IV, V, and VI for minimal reactivity. |
| Source | Pooled antisera from goats hyperimmunized with type I collagen |
| Gene Symbol | COL1A1, COL1A2 |
|---|---|
| Gene Full Name | collagen type I alpha 1 chain |
| Alias Symbols | OI1, OI2, OI3, OI4, EDSC, CAFYD, EDSARTH1 |
| NCBI Gene Id | 1277; 1278 |
| Protein Name | collagen alpha-1(I) chain |
| Description of Target | This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. |
| Uniprot ID | P02452, P08123 |
| Protein Accession # | NP_000079.2 |
| Nucleotide Accession # | NM_000088.3 |