TSG101 Antibody - C-terminal region
Cat# ARP38773_T100-25UL
Size : 25ul
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
TSG101 Antibody - C-terminal region (ARP38773_T100)
| Datasheets/Manuals | Printable datasheet for anti-TSG101 (ARP38773_T100) antibody |
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| Tested Species Reactivity | Human, Rat |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human TSG101 |
| Purification | Protein A purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: TIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY |
| Concentration | 1.0 mg/ml |
| Blocking Peptide | For anti-TSG101 (ARP38773_T100) antibody is Catalog # AAP38773 (Previous Catalog # AAPP20978) |
| Sample Type Confirmation | TSG101 is supported by BioGPS gene expression data to be expressed in HepG2 |
| Enhanced Validation | Relative Expression (Western Blot)  |
| Reference | Surjit,M., et al., (2006) J. Biol. Chem. 281 (12), 8135-8142 |
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| Gene Symbol | TSG101 |
| Gene Full Name | Tumor susceptibility gene 101 |
| Alias Symbols | TSG10, VPS23 |
| NCBI Gene Id | 7251 |
| Protein Name | Tumor susceptibility gene 101 protein |
| Description of Target | TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. TSG101 contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. TSG101 may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of TSG101 appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in TSG101 gene occur in high frequency in breast cancer. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. |
| Uniprot ID | Q99816 |
| Protein Accession # | NP_006283 |
| Nucleotide Accession # | NM_006292 |
| Protein Size (# AA) | 390 |
| Molecular Weight | 44 kDa |
| Protein Interactions | USHBP1; CEP55; VPS37C; VPS28; AATF; MGRN1; PDLIM7; TAX1BP1; KRT31; KRT13; KIFC3; DAPK3; AR; FAM9B; VPS37A; HAUS1; SYCE1; UBC; LRSAM1; ADRB2; MVB12A; UBAP1; CDKN1A; HGS; gag; gag-pol; GRB2; CDS2; ZFYVE9; VCP; VPS37B; WDR12; XPO1; UBD; ARRDC1; KCNN4; RAB11F |
