Biological Activity

Tezacaftor (VX-661) is the second F508del CFTR correction compound that assists the CFTR protein to reach the cell surface.

Chemical Information

Molecular Weight	520.5
Formula	C26H27F3N2O6
CAS Number	1152311-62-0
Solubility (25°C)	DMSO 90 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Ana M Matos, et al. Treatment of Polarized Cystic Fibrosis Airway Cells With HGF Prevents VX-661-Rescued F508del-CFTR Destabilization Caused by Prolonged Co-exposure to VX-770

[2] Gabriella Fűr, et al. Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX-661 + VX-770 treatment on disease severity

[3] Sheridan M Hoy. Elexacaftor/Ivacaftor/Tezacaftor: First Approval

[4] Peter G Middleton, et al. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele