TET2 Antibody
Cat# OAGA08443
Size : 100ul
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for TET2 Antibody (OAGA08443) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Monoclonal |
| Clone | GT411 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | Unconjugated |
| Application | IP|WB |
| Reconstitution and Storage | -20°C or -80°C|2°C to 8°C |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human TET2. The exact sequence is proprietary. |
| Purification | Protein G Purified |
| Concentration | 1 mg/ml |
| Application Info | Suggested starting dilutions are as follows: IP: 1:100-1:500, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Storage Buffer | PBS |
| Gene Symbol | TET2 |
|---|---|
| Gene Full Name | tet methylcytosine dioxygenase 2 |
| Alias Symbols | IMD75, KIAA1546, MDS, methylcytosine dioxygenase TET2, probable methylcytosine dioxygenase TET2, ten-eleven translocation 2, tet oncogene family member 2. |
| NCBI Gene Id | 54790 |
| Protein Name | Methylcytosine dioxygenase TET2 |
| Description of Target | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. |
| Uniprot ID | Q6N021 |
| Protein Accession # | NP_001120680.1 |
| Nucleotide Accession # | NM_001127208.2 |
