• Specifications

    Product Description

    APC conjugated mouse monoclonal antibody raised against a full length recombinant SH2D1A.small size,trial size,MAB,monoclonal Ab,monoclonal antibody

    Immunogen

    SH2D1A (AAH20732, 1 a.a. ~ 128 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

    Sequence

    MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP

    Host

    Mouse

    Reactivity

    Human

    Interspecies Antigen Sequence

    Mouse (88); Rat (89)

    Conjugation

    APC

    Isotype

    IgG2a Kappa

    Quality Control Testing

    Antibody Reactive Against Recombinant Protein.

    Storage Buffer

    In 1x PBS, pH 7.4

    Storage Instruction

    Store at 4°C.

  • Applications

    Flow Cytometry

    Immunofluorescence

    Protocol Download

    Western Blot

  • Gene Info — SH2D1A

    Entrez GeneID

    4068

    GeneBank Accession#

    BC020732

    Protein Accession#

    AAH20732

    Gene Name

    SH2D1A

    Gene Alias

    DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD

    Gene Description

    SH2 domain protein 1A

    Omim ID

    300490 308240

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    Duncan's disease|OTTHUMP00000023976|SLAM-associated protein|T cell signal transduction molecule SAP|signaling lymphocyte activation molecule-associated protein

  • Interactomes
  • Pathways
  • Diseases
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