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> Polymyxin B [1404-26-8]

Polymyxin B [1404-26-8]

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Cat# HY-149179-100mg

Size : 100mg

Brand : MedChemExpress

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Description

Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].

In Vitro

Polymyxin B (10 μg/mL, 6 h) decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) [3].
Polymyxin B shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polymyxin B Related Antibodies
In Vivo

Polymyxin B (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model[2].
Polymyxin B (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old, 24-30 g, female Swiss mice[2]
Dosage: 0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection model
Administration: S.c.
Result: Showed antibacterial activities for three K. pneumoniae strains.
Animal Model: 7-9 weeks, female NMRI mice (E. coli IH3080)[3]
Dosage: 2 mg/kg
Administration: S.c.
Result: Decreased the bacterial count in a dose dependent manner.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[Polymyxin B]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.5 M HCl : ≥ 50 mg/mL

H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with HCl)

H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with 1 M HCl)

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References