Size : 25mg
Phone : +1 850 650 7790
Synonyms:
| Description | Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. |
| In vitro | Neurotensin induces the expression of inflammatory markers (MIP-2, MCP-1, IL-1β, TNFα) in murine microglial cells and promotes IL-8 secretion in colon epithelial cells harboring the NTR, a high-affinity receptor belonging to the GPCR family, prevalent in many pancreatic and colorectal cancers. This suggests Neurotensin's potential endocrine role in tumor growth. Acting through NTR1, it activates several signal transduction pathways, including intracellular calcium levels, MAPKs (ERK, JNK), and PKC isoforms. In HCT116 cancer cells, Neurotensin dramatically enhances migration approximately threefold, an effect inhibited by Curcumin pretreatment. Additionally, Neurotensin's activation of the MEK/ERK pathway and subsequent upregulation of AP-1 transcription factors underscore its contribution to cell proliferation. |
| Molecular Weight | 1672.92 |
| Formula | C78H121N21O20 |
| Cas No. | 39379-15-2 |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CC(C)C)C(O)=O |
| Relative Density. | 1.46g/cm3 |
| Sequence | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu |
| Sequence Short | XLYENKPRRPYIL |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 36.43 mg/mL (21.78 mM), Sonication is recommended.  DMSO: 10 mM, Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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