| Size | |
|---|---|
| 100µg | Inquiry |
Dispatch Time: About 3 working days
- Product Name
- NCAM1 antibody
- Catalogue No.
- FNab05575
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 0D10
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- neural cell adhesion molecule 1
- Alternative Names
- Neural cell adhesion molecule 1 (N-CAM-1 antibody, NCAM-1)|NCAM1|NCAM antibody
- UniProt ID
- P13591
- Observed MW
- 140 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:1000-1:10000; IHC: 1:200-1:1000
Validated Images
fetal human brain tissue were subjected to SDS PAGE followed by western blot with FNab05575(NCAM1 Antibody) at dilution of 1:4000 
Immunohistochemistry of paraffin-embedded human small cell lung carcinoma tissue slide using FNab05575(NCAM1 Antibody) at dilution of 1:800 Heat mediated antigen retrieved with Tris-EDTA buffer(pH9). - Background
- Neural cell adhesion molecule 1(NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin(Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA(PMID: 9696812). The glycosylphosphatidylinositol(GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats(FNIII). All three forms can be posttranslationally modified by addition of polysialic acid(PSA)(PMID: 14976519). Several other isofroms have also been described(PMID: 1856291).