1. MMP-12 facilitates macrophage accumulation and activation in anti-GBM glomerulonephritis which is required for glomerular crescent formation, Bowman's capsule rupture, tubular damage and renal function decline.
2. findings define a novel physiological function of Shp2 in TGF-beta1/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.
3. Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice
4. MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV and fibronectin.
5. MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.
6. These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.
7. study found significant increases of MMP-3 and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection
8. The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 might be related to MMP-12 production.
9. MMP-12 up-regulation mediated by SARM-TRIF signaling pathway contributes to IFN-gamma-independent airway inflammation and AHR post RSV infection in nude mice.
10. MMP-12 and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
11. Post-MI, MMP-12i impaired CD44-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.
12. MMP12 upregulated in regenerating motor neurons of the mouse and rat facial nucleus; findings point to a role of MMP12 in the neuronal initiation of the synaptic stripping process
13. abnormal neuronal expression of matrix metalloproteinase-12 may contribute to axonal degeneration in Niemann-Pick type C disease
14. the results of this study show a close correlation between vascular injury markers, Arg 1+ macrophage accumulation and fibrosis and suggest an important role of MMP-12 in regulating these processes.
15. A novel systemic role for MMP12 in postnatal adipose tissue expansion and smoking-associated weight loss by suppressing vascularity within the white adipose tissue depots.
16. Our results suggest that MMP12 released by macrophages activated on dehydrated airway surfaces may play an important role in emphysema formation in the absence of cigarette smoke exposure.
17. Macrophage MMP12 regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.
18. Gene expression of Mmp-12 and Mmp-13, and Timp-1 was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2, and Mmp-9 expression was modest.
19. MMP12 has a protective effect on corneal fibrosis during wound repair through regulation of immune cell infiltration and angiogenesis.
20. Ethanol treatment increases MMP-12 expression in murine peritoneal macrophages RAW 264.7 macrophages.
21. Thus, our study suggested that the upregulated cerebral MMP-12 during aging enhances aging-associated neuroinflammation by facilitating recruitment of bone marrow-derived microglia into the brain.
22. MMP-12 is a key regulator of macrophage infiltration and inflammation, contributing to retinal vascular dysfunction and pathological angiogenesis.
23. Results suggest macrophage-derived MMP-12 contributes to angiostasis in the ischemic lung.
24. MMP-12 does not seem to be essential for macrophage infiltration in adipose tissue, but contributes to the formation of crown-like structures crown-like structures
25. the endogenous matrix metalloprotease-12 active form can be detected with a novel broad spectrum activity-based probe
26. Tanshinone IIA inhibits cell proliferation and TF and MMP-12 expressions in RAW264.7 cells stimulated by ox-LDL.
27. Pneumocystis murina exposure induced Mmp12 mRNA expression in whole lungs and alveolar macrophages in mice.
28. analysis of orally potent and selective small molecule inhibitor of MMP-12 for treatment of COPD and asthma in human and mouse models
29. Macrophage-derived MMP-12 regulates elastin degradation even in progressive experimental liver fibrosis.
30. Provide in vivo evidence of an effect of MMP12 on fibrinogen level.
31. Macrophage metalloelastase (MME) inversely correlates with the expression of bFGF and tumor angiogenesis in a model of murine colon cancer.
32. MMP-12 leads to elastin degradation in eosinophilic meningitis caused by Angiostrongylus cantonensis.
33. MMP12-induced myeloid cell autonomous defect led to abnormal myelopoiesis, immune suppression, and lung adenocarcinoma
34. Selective MMP-12 inhibitor retards atherosclerosis development and results in a more fibrous plaque phenotype in mice.
35. These results suggest that experimental autoimmune encephalomyelitis disease activity may be modulated by the cleavage of osteopontin by matrix metalloproteinase-12.
36. This study examined the hypothesis that the control of NADPH oxidase-2 (Nox2)-mediated reactive oxygen species (ROS) regulates the expression of matrix metalloproteinases (MMPs) and the migration of macrophages.
37. these data suggest important counter-regulatory roles between MMP12 and ECM-degrading enzymes like MMP2, MMP9, and MMP13 in Th2 cytokine-driven fibrosis.
38. MMp12 expression correlates with virulence following neurotropic mouse hepatitis virus infection
39. the role of matrix metalloproteinases-12 in IL-13-induced inflammation and remodeling in the lung
40. conclude that acute smoke-induced connective tissue breakdown, the precursor to emphysema, requires both neutrophils and macrophage metalloelastase
41. Migration of monocytes/macrophages in vitro and in vivo is accompanied by MMP12-dependent tunnel formation and by neovascularization.
42. Increased MMP-12 expression after spinal cord trauma is deleterious and contributes to the development of secondary injury
43. osteoclasts are able to express MMP-12, but MMP-12 did not appear critical for osteoclast recruitment or resorption
44. MMP-12 deficiency conferred significant protection against transmedial elastin degradation and ectasia in the atherosclerotic media. MMP-12 is not involved in atherosclerotic plaque growth.
45. Oligodendrocytes express MMP-12 during their maturation. MMP-12 has functional involvement both in maturation of oligodendrocyte precursor cells & in the ability of OPCs and OLs to extend processes.
46. MMP-12 deficiency attenuates abdominal aortic aneurysmgrowth, possibly by decreasing macrophage recruitment.
47. SP-D influences innate host defense, in part, by regulating sCD14 in a process mediated by MMP-9 and MMP-12.
48. NADPH oxidase restrains the MMP-12 activity of macrophages
49. MMP-12 has a role in inflammation and in T effector polarization
50. Asbestos causes significant increases in mRNA levels of lung matrix metalloproteinases (MMPs 12 and 13) and tissue inhibitor of metalloproteinases (TIMP1), as well as increased activities of MMP 2, 9, and 12 in BAL fluid.

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