pt en es

Reagents and instruments for immunology, cell biology and molecular biology.

Loganic acid [22255-40-9]

Print

Cat# NB-64-37954-2mg

Size : 2mg

Contact local distributor :

Phone : +1 850 650 7790

Brand : Neo Biotech

Request more information

Contact local distributor :

Phone : +1 850 650 7790

Remove All

Loganic acid

(Synonyms: Loganate) Copy Product Info

Synonyms: Loganate

Catalog No. T6S1440 Copy Product Info

Purity: 99.45%

1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.

Cas No. 22255-40-9

For research use only—not for human use. No sales to individuals. Use as intended only.

Select Batch

Purity:99.45%

Color:White to Yellow

Product Introduction

Loganic acid AI Summary

Loganic acid exhibits antiviral activity against HCV by inhibiting viral entry and replication in human Huh7 cells, with inhibition percentages of 39.4% and 52.5% at different time points, and an IC50 value of 11.0 µg/mL in inhibiting viral replication after 72 hours by NS5A staining. Additionally, this compound shows significant inhibitory activity in both OATP1B1 and OATP1B3-transfected CHO cells, with 49.18% inhibition of sodium fluorescein uptake in OATP1B1 cells and 99.49% inhibition in OATP1B3 cells at a concentration of 10 µM. Furthermore, Loganic acid exhibits inhibitory activity on both COX1 and COX2 enzymes, showing moderate inhibition of COX1 with percentages between 36.0% and 36.9% at 10 µM and 35 µM concentrations, and potent inhibition of COX2 with inhibition percentages between 80.8% and 84.0% at the same concentrations, though this activity significantly decreases to ≤30.0% at 100 µM. These characteristics suggest that Loganic acid has multifaceted bioactivity with potential applications in antiviral therapy and enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.
Synonyms	Loganate

Chemical Properties

Molecular Weight	376.36
Formula	C₁₆H₂₄O₁₀
Cas No.	22255-40-9
Smiles	21[C@]12C[C@H](O)[C@H](C)[C@@]1(21)[C@H](O[C@]1(21)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2C(O)=O
Relative Density.	1.6g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (664.26 mM), Sonication is recommended.

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

H2O: 1 g/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6570 mL	13.2852 mL	26.5703 mL	132.8515 mL
5 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
10 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL
20 mM	0.1329 mL	0.6643 mL	1.3285 mL	6.6426 mL
50 mM	0.0531 mL	0.2657 mL	0.5314 mL	2.6570 mL
100 mM	0.0266 mL	0.1329 mL	0.2657 mL	1.3285 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

scavengingradicalLoganic acidInhibitorinhibitatherosclerosis

Related Tags: Loganic acid chemical structure | Loganic acid formula | Loganic acid molecular weight