L-Aspartic acid [56-84-8]
Cat# NB-64-18867-500mg
Size : 500mg
Brand : Neo Biotech
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Phone : +1 850 650 7790
L-Aspartic acid (Synonyms: L-Aspartate, Aspatofort, Asparagic acid)
Catalog No. T2O2731 Copy Product Info
Purity: 99.80%
L-Aspartic acid (Aspatofort) is a non-essential amino acid in humans, L-Aspartic acid has an overall negative charge and plays an important role in the synthesis of other amino acids and in the citric acid and urea cycles. Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid. L-Aspartic acid also serves as a neurotransmitter.
L-Aspartic acid
Copy Product InfoSynonyms L-Aspartate, Aspatofort, Asparagic acid
L-Aspartic acid (Aspatofort) is a non-essential amino acid in humans, L-Aspartic acid has an overall negative charge and plays an important role in the synthesis of other amino acids and in the citric acid and urea cycles. Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid. L-Aspartic acid also serves as a neurotransmitter.
Cas No. 56-84-8
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Purity:99.80%
Appearance:Solid
Color:White
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Product Introduction
L-Aspartic acid AI Summary
L-Aspartic acid exhibits a broad spectrum of bioactivity and physicochemical properties across various assays and biological systems. It activates multiple carbonic anhydrase isozymes, including human carbonic anhydrase I (KA 48.0 μM), II (KA 130.0 μM), and bovine carbonic anhydrase IV (KA 60.0 μM). It also activates Leishmania donovani chagasi carbonic anhydrase (KA 0.3 μM) and moderately activates Trypanosoma cruzi carbonic anhydrase (KA 18.7 μM). The compound shows agonistic activity at mGlu receptors (EC50 > 1,000,000 nM) and inhibits N-methyl-D-aspartate glutamate receptor binding with moderate potency (IC50 = 1638.0 nM). With a high partition coefficient (logP = 4.01) and a pKa of 9.67, L-Aspartic acid is lipophilic, suggesting good membrane permeability. It demonstrates uptake and growth reversal in various cell lines, including H4, MH1C1, and 7800C1 cells. Additionally, it shows 17.0% residue fraction and a half-life of 2.867 hours in ischemic myocardial tissue in dogs. In antiviral studies, it inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells (10 μM concentration) but shows limited efficacy in other SARS-CoV-2 assays. L-Aspartic acid modulates excitatory amino acid transporters (EAATs) and inhibits HDAC6, pyruvate carboxylase (Ki = 700.0 nM), and shows binding to sodium-coupled aspartate transporters (Kd = 1.0 - 94.0 nM). However, it has limited antiviral potency against SARS-CoV-2 in VERO-6 cells and other systems. Overall, L-Aspartic acid’s versatile bioactivity spectrum and lipophilic nature indicate potential applications in drug development targeting diverse biological systems and diseases, albeit with varying degrees of efficacy..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Aspartic acid (Aspatofort) is a non-essential amino acid in humans, L-Aspartic acid has an overall negative charge and plays an important role in the synthesis of other amino acids and in the citric acid and urea cycles. Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid. L-Aspartic acid also serves as a neurotransmitter. |
| Synonyms | L-Aspartate, Aspatofort, Asparagic acid |
| Molecular Weight | 133.1 |
| Formula | C4H7NO4 |
| Cas No. | 56-84-8 |
| Smiles | [C@H](CC(O)=O)(C(O)=O)N |
| Relative Density. | 1.66. Temperature:13 °C.;1.661. Temperature:13 °C. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 8 mg/mL (60.11 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
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