IL-1 alpha/IL-1A Protein, Human, Recombinant
Cat# NB-64-56048-10ug
Size : 10ug
Brand : Neo Biotech
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IL-1 alpha/IL-1A Protein, Human, Recombinant
(Synonyms: interleukin 1, α, interleukin 1, alpha, IL1-α, IL-1F1, IL1F1, IL1-ALPHA, IL-1A, IL-1 α/IL1A, IL1) Copy Product InfoSynonyms: interleukin 1, α, interleukin 1, alpha, IL1-α, IL-1F1, IL1F1, IL1-ALPHA, IL-1A, IL-1 α/IL1A, IL1
Catalog No. TMPY-00854 Copy Product Info
Purity: 95.2%
IL-1 alpha/IL-1A Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18 kDa and the accession number is P01583.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.2%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.07-0.35 ug/mL. |
| Description | IL-1 alpha/IL-1A Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18 kDa and the accession number is P01583. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | Tag Free |
| Accession Number | P01583 |
| Construction | The processed form of human IL1α (NP_000566.3) (Ser 113-Ala 271) was expressed and purified. Predicted N terminal: Ser 113 |
| Protein Purity | > 95 % as determined by SDS-PAGE  |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Synonyms | interleukin 1, α, interleukin 1, alpha, IL1-α, IL-1F1, IL1F1, IL1-ALPHA, IL-1A, IL-1 α/IL1A, IL1 |
| Research Background | IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 18 kDa (predicted); 22 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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IL-1IL 1
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Related Tags: IL-1 alpha/IL-1A Protein, Human, Recombinant chemical structure | IL-1 alpha/IL-1A Protein, Human, Recombinant molecular weight
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