IDO1 Mouse Monoclonal Antibody [Clone ID: UMAB126]
Cat# UM500091CF
Size : 100ug
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IDO1 Mouse Monoclonal Antibody [Clone ID: UMAB126]
SKU
UM500091CF
Carrier-free (BSA/glycerol-free) IDO1 mouse monoclonal antibody,clone UMAB126
| Product Data | |
| Clone Name | UMAB126 |
|---|---|
| Application | 10k-ChIP, IF, IHC, WB |
| Recommended Dilution | IHC 1:100~200 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human IDO1(NP_002155) produced in HEK293T cell. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 45.1 kDa |
| Gene Name | indoleamine 2,3-dioxygenase 1 |
| Database Link | |
| Background | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. provided by RefSeq, Feb 2011 |
| Synonyms | IDO; IDO-1; INDO |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Metabolic pathways, Tryptophan metabolism |
| Product Manuals |
| FAQs |
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| SDS |
| Antibody Resources |
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| SKU | Description | Size | ||
|---|---|---|---|---|
| UM500091 | IDO1 mouse monoclonal antibody,clone UMAB126 | 100 ul | | |
| UM570091 | IDO1 mouse monoclonal antibody,clone UMAB126 | 30 ul | | |
Citations
Regorafenib plus avelumab in advanced gastroenteropancreatic neuroendocrine neoplasms: a phase 2 trial and correlative analysis
Cousin, Guégan, Palmieri et al
Nat Cancer (2025) 6 (4), 584-594 DOI: 10.1038/s43018-025-00916-3
Cousin, Guégan, Palmieri et al
Nat Cancer (2025) 6 (4), 584-594 DOI: 10.1038/s43018-025-00916-3
Cited by 10
AI Summary: OriGene’s IDO1 antibody (UMAB126) was used for immunohistochemical analysis to assess IDO1 expression as a potential biomarker of resistance in this study of regorafenib plus avelumab in advanced gastroenteropancreatic neuroendocrine neoplasms.
Snippet: PD1 (NAT105, Cell Marque), PD-L1 (QR-1, Diagomics), IDO1 (UMAB126, Origene) and PanCK (AE1/AE3/PCK26, Ventana). Bound primary antibodies were detected using OmniMap horseradish peroxidase (HRP)-conjugated anti-rabbit IgG (760-4311, Ventana) or OmniMap HRP-conjugated anti-mouse IgG (760-4310, Ventana)
Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases
Smalley, Chen, Phadke et al
Clin Cancer Res (2021)
Smalley, Chen, Phadke et al
Clin Cancer Res (2021)
AI Summary: OriGene's anti-IDO1 antibody was used in this study to validate key findings by immunohistochemistry, helping to characterize the immune microenvironment of melanoma brain and leptomeningeal metastases.
Snippet: Park, California) and antibodies against LAMP3 (Abcam, Cambridge, United Kingdom), IDO1 (Origene, Rockville, MD), and CCL19 (Invitrogen, Carlsbad, CA). Slides were imaged using the Vectra 3 Automated Quantitative Pathology Imaging System
Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression
Heng, Bilgin, Lovejoy et al
Breast Cancer Res (2020) 22 (1), 113 DOI: 10.1186/s13058-020-01351-1
Heng, Bilgin, Lovejoy et al
Breast Cancer Res (2020) 22 (1), 113 DOI: 10.1186/s13058-020-01351-1
Cited by 58
AI Summary: In this study, OriGene products—including the KMO and KYNU antibodies—were used for western blot and immunohistochemistry analyses to assess protein expression of key kynurenine pathway enzymes in breast cancer subtypes, enabling the identification of their upregulation in aggressive cancers.
Differential kynurenine pathway metabolism in highly-metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression
Heng, Bilgin, Lovejoy et al
Research Square (2020)
Heng, Bilgin, Lovejoy et al
Research Square (2020)
Snippet: hour. Blots were probed overnight at 4°C with primary antibodies: IDO1 (1:1000;clone: UMAB126, Origene), KMO (1:1000;LSBio), kynureninase (KYNU) (1:500;clone: OTI1H1, Origene) and actin (1:1000;Abcam). Secondary
Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype
Takada, Toyokawa, Kinoshita et al
J. Cancer Res. Clin. Oncol. (2020)
Takada, Toyokawa, Kinoshita et al
J. Cancer Res. Clin. Oncol. (2020)
Cited by 14
AI Summary: OriGene’s UMAB126 antibody was used for immunohistochemical detection of IDO1 expression in tumor cells, contributing to the analysis of immune-related markers in early-stage lung adenocarcinoma subtypes in this study.
Snippet: clone 22C3 antibody was also used in randomly selected specimens (N = 46) from Groups A and B. Immunohistochemistry for PD-L2 (clone 176611, R&D Systems, Minneapolis, MN, USA) and immunohistochemistry for IDO1 (clone UMAB126, Origene Technologies;- clone 22C3 antibody was also used in randomly selected specimens (N = 46) from Groups A and B. Immunohistochemistry for PD-L2 (clone 176611, R&D Systems, Minneapolis, MN, USA) and immunohistochemistry for IDO1 (clone UMAB126, Origene Technologies
Programmed death ligand 1/indoleamine 2,3-dioxygenase 1 expression and tumor-infiltrating lymphocyte status in renal cell carcinoma with sarcomatoid changes and rhabdoid features
Kiyozawa, Takamatsu, Kohashi et al
Hum. Pathol. (2020) 101, 31-39 DOI: 10.1016/j.humpath.2020.04.003
Kiyozawa, Takamatsu, Kohashi et al
Hum. Pathol. (2020) 101, 31-39 DOI: 10.1016/j.humpath.2020.04.003
Cited by 13
AI Summary: OriGene’s IDO1 monoclonal antibody (clone UMAB126, UM500091) was used to detect IDO1 expression in tumor samples, enabling the study’s analysis of immune marker expression in renal cell carcinoma with sarcomatoid and rhabdoid features.
Snippet: The primary monoclonal antibodies used were as follows: PD-L1 (rabbit monoclonal, clone 28-8, 1:400, ab205921;Abcam), IDO1 (mouse monoclonal, clone UMAB126, 1:200, UM500091;OriGene Technologies), CD3 (mouse monoclonal, clone PS1, pre-dilution, 413241;- The primary monoclonal antibodies used were as follows: PD-L1 (rabbit monoclonal, clone 28-8, 1:400, ab205921
Showing 1-6 of 12 papers.
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