Human ZAP-70 Antibody : AP
Cat# OASB02221
Size : 1.0mL
Brand : Aviva Systems Biology
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Phone : +1 850 650 7790
Human ZAP-70 Antibody : AP (OASB02221)
| Datasheets/Manuals | Printable datasheet for Human ZAP-70 Antibody : AP (OASB02221) |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | Liquid. 50 mM Tris/1 mM MgCl2/50% Glycerol containing 0.1% sodium azide, pH 8.0 |
| Clonality | Monoclonal |
| Host | Mouse |
| Conjugation | AP |
| Additional Information | Description: ZAP-70 is a protein tyrosine kinase (PTK) with the primary role of catalyzing the phosphorylation of tyrosine residues in cellular proteins, and thus, contributes significantly to the initiation of cell signaling. ZAP-70 is normally expressed on T cell and NK cells. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Human ZAP-70 (a.a. 280-309) |
| Concentration | Lot specific |
| Specificity | ZAP-70 |
| Gene Symbol | ZAP70 |
|---|---|
| Gene Full Name | zeta chain of T cell receptor associated protein kinase 70 |
| Alias Symbols | SRK, STD, TZK, STCD, IMD48, ADMIO2, ZAP-70 |
| NCBI Gene Id | 7535 |
| Protein Name | tyrosine-protein kinase ZAP-70 |
| Description of Target | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. |
| Uniprot ID | P43403 |
| Protein Accession # | NP_001070.2 |
| Nucleotide Accession # | NM_001079.3 |
