Human 5-lipoxygenase (5-LO) ELISA Kit
Cat# MBS261618-96
Size : 96-Strip-Wells
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
5-Lipoxygenase (5-LO) ELISA Kit for Human
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS261618MBS261618 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5-lipoxygenase (5-LO) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or… More details
Product Overview
Online Datasheet in PDFProduct Name
5-lipoxygenase (5-LO), ELISA Kit
Full Product Name
Human 5-lipoxygenase (5-LO) ELISA Kit
Product Gene Name
5-LO elisa kit
Species Reactivity
Human
Assay Type
Sandwich (Quantitative)
Samples
human serum, plasma or cell culture supernatant and organizations in the natural and recombinant 5-LO concentration.
Detection Range
10 ng/ml-0.156 ng/ml
Sensitivity
Up to 0.05 ng/ml.
Specificity
No cross-reaction with other factors.
Preparation and Storage
Store all reagents at 2-8 degree C.
Inter-assay Precision
<= 12%
Intra-assay Precision
<= 8%
Molecular Weight
56,291 Da
OMIM
152390
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of 5-LO elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for 5-LO. It may not necessarily be applicable to this product.
NCBI Official Full Name
5-lipoxygenase, partial
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase
NCBI Official Symbol
ALOX5
NCBI Official Synonym Symbols
5-LO; 5LPG; LOG5; 5-LOX
UniProt Protein Name
Arachidonate 5-lipoxygenase
Protein Family
Arachidonate 5-lipoxygenase
UniProt Gene Name
ALOX5
UniProt Synonym Gene Names
LOG5; 5-LO; 5-lipoxygenase
UniProt Entry Name
LOX5_HUMAN
NCBI Protein Information
arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform
NCBI Summary for 5-LO
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Show more UniProt Comments for 5-LO
5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.
Protein type: Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Oxidoreductase; Nuclear envelope; EC 1.13.11.34
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol
Molecular Function: protein binding; iron ion binding; arachidonate 5-lipoxygenase activity
Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process
Disease: Asthma, Susceptibility To
Show more Protein type: Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Oxidoreductase; Nuclear envelope; EC 1.13.11.34
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol
Molecular Function: protein binding; iron ion binding; arachidonate 5-lipoxygenase activity
Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process
Disease: Asthma, Susceptibility To
Research Articles on 5-LO
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with 5-LO elisa kit
| Reference Product | PubMed Publications |
|---|---|
| PTGS2 elisa kit | >255 publications with 5-LO and PTGS2 |
| ALOX5AP elisa kit | >195 publications with 5-LO and ALOX5AP |
| PTGS1 elisa kit | >103 publications with 5-LO and PTGS1 |
| PLA2G4A elisa kit | >56 publications with 5-LO and PLA2G4A |
| LTA4H elisa kit | >26 publications with 5-LO and LTA4H |
| LTC4S elisa kit | >25 publications with 5-LO and LTC4S |
| COTL1 elisa kit | >9 publications with 5-LO and COTL1 |
| MAPKAPK2 elisa kit | >7 publications with 5-LO and MAPKAPK2 |
Pathways associated with 5-LO elisa kit
| Products by Pathway | Pathway Diagram |
|---|---|
| Arachidonic Acid Metabolism Pathway antibodies | Arachidonic Acid Metabolism Pathway Diagram |
| Arachidonic Acid Metabolism Pathway antibodies | Arachidonic Acid Metabolism Pathway Diagram |
| Arachidonic Acid Metabolism Pathway antibodies | Arachidonic Acid Metabolism Pathway Diagram |
| Eicosanoid Synthesis Pathway antibodies | Eicosanoid Synthesis Pathway Diagram |
| IL-5 Signaling Pathway antibodies | IL-5 Signaling Pathway Diagram |
| Metabolism Pathway antibodies | Metabolism Pathway Diagram |
| Metabolism Of Lipids And Lipoproteins Pathway antibodies | Metabolism Of Lipids And Lipoproteins Pathway Diagram |
| Ovarian Steroidogenesis Pathway antibodies | Ovarian Steroidogenesis Pathway Diagram |
| Ovarian Steroidogenesis Pathway antibodies | Ovarian Steroidogenesis Pathway Diagram |
| Selenium Pathway antibodies | Selenium Pathway Diagram |
Diseases associated with 5-LO elisa kit
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >539 publications with 5-LO and Inflammation |
| Neoplasms Antibodies | >308 publications with 5-LO and Neoplasms |
| Asthma Antibodies | >237 publications with 5-LO and Asthma |
| Lung Diseases Antibodies | >221 publications with 5-LO and Lung Diseases |
| Atherosclerosis Antibodies | >113 publications with 5-LO and Atherosclerosis |
| Necrosis Antibodies | >105 publications with 5-LO and Necrosis |
| Edema Antibodies | >94 publications with 5-LO and Edema |
| Drug Toxicity Antibodies | >88 publications with 5-LO and Drug Toxicity |
| Neoplasms, Experimental Antibodies | >51 publications with 5-LO and Neoplasms, Experimental |
| Pain Antibodies | >47 publications with 5-LO and Pain |
Organs/Tissues associated with 5-LO elisa kit
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >1096 publications with 5-LO and Blood |
| Lung Antibodies | >244 publications with 5-LO and Lung |
| Brain Antibodies | >121 publications with 5-LO and Brain |
| Muscle Antibodies | >113 publications with 5-LO and Muscle |
| Bone Antibodies | >75 publications with 5-LO and Bone |
| Heart Antibodies | >67 publications with 5-LO and Heart |
| Kidney Antibodies | >64 publications with 5-LO and Kidney |
| Bone Marrow Antibodies | >56 publications with 5-LO and Bone Marrow |
| Intestine Antibodies | >45 publications with 5-LO and Intestine |
| Prostate Antibodies | >37 publications with 5-LO and Prostate |
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