Calcitriol (Vitamin D3)

The biologically active form of Vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic.

Synonyms:
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; (1α,3β,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol,; 1α,25-Dihydroxycholecalciferol; 1α,25-Dihydroxyvitamin D3; Calcijex; Dihydroxyvitamin D3; Panbonis; Ro 21-5535; Rocaltrol; Silkis; Solbone P; Soltriol; Topitriol; Toptriol

CAS No:
32222-06-3

Molecular Formula:
C₂₇H₄₄O₃

Molecular Weight:
416.64

Purity:
≥95%

Appearance:
Supplied as a white solid

Melting Point:
>94ºC (dec)

Solubility:
Chloroform (Slightly), Methanol (Slightly)

Atmosphere:
Inert Gas

Method for Determining Identity:
Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis

TLC Conditions:
SiO2; Dichloromethane: Methanol=9:1; Visualized with UV and AMCS; Single Spot, Rf=0.40

Elemental Analysis:
Calculated: %C: 77.83; %H: 10.64

Water Content (Karl Fischer):
As Reported

Specific Rotation (c=0.1, Methanol):
As Reported

Storage and Stability:
Long-term storage is recommended at -70°C under Inert gas. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Air and temperature sensitive. Store under Inert atmophere.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards: 
All products should be handled by qualified personnel only, trained in laboratory procedures.