| Short Description : | Rabbit polyclonal anti-Phospho-MEK5-Ser311/Thr315 for use in WB in Rat, Bovine, Canine, Chicken, Human, Non-Human Primates, Mouse, Xenopus and Zebrafish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Rat/Bovine/Canine/Chicken/Human/Non-Human Primates/Mouse/Xenopus/Zebrafish |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: | WB 1:1000 |
| Formulation: | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
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| Immunogen: | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser311/Thr315 conjugated to KLH. |
| Tissue Specificity | Isoform Alpha-1: Expressed in the liver and brain (at protein level). Isoform Alpha-2: Expressed in the liver and brain (at protein level). Isoform Beta: Expressed in the liver, muscle, testes, lung, kidney, spleen, heart and brain (at protein level). |
| Post Translational Modifications | Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. |
| Function | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 5Map Kinase Kinase 5Mapkk 5Mapk/Erk Kinase 5Mek 5 |
| Database Links | |
| Cellular Localisation | Isoform Beta: CytoplasmCytosolIsoform Alpha-1: MembraneThe Alternatively Spliced Exon In Alpha Isoform Resemble Conserved Sequences That Mediate Interactions With The CytoskeletonThereby Explaining The Differential LocalizationIsoform Alpha-2: Membrane |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 antibodyAnti-Map Kinase Kinase 5 antibodyAnti-Mapkk 5 antibodyAnti-Mapk/Erk Kinase 5 antibodyAnti-Mek 5 antibodyAnti-Map2k5 antibodyAnti-Mek5 antibodyAnti-Mkk5 antibodyAnti-Prkmk5 antibody |
Information sourced from Uniprot.org