| Short Description : | Mouse monoclonal anti-Actin, cytoplasmic 1 for use in IF, WB and IHC in Human, Rat, Mouse, Monkey, Dog, Chicken, Hamster, Rabbit and Insect samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IF/WB/IHC |
| Host: | Mouse |
| Reactivity: | Human/Rat/Mouse/Monkey/Dog/Chicken/Hamster/Rabbit/Insect |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 5B7 |
| Isotype: | IgG1 |
| Conjugation: | HRP |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was purified using affinity-chromatography using specific immunogen. |
| Dilution Range: | Optimal working dilutions should be determined experimentally by the investigator Suggested starting dilutions are as follows: WB 1:2000-5000 |
| Formulation: | Liquid in PBS pH7.4, containing 0.02% Sodium Azide and 50% Glycerol. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
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| Specificity: | Beta-actin Monoclonal Antibody (5B7) specially designed for your Western blot as internal control. |
| Function | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | Actin - Cytoplasmic 1Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed |
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| Cellular Localisation | CytoplasmCytoskeletonNucleusLocalized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
| Alternative Antibody Names | Anti-Actin - Cytoplasmic 1 antibodyAnti-Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed antibodyAnti-ACTB antibody |
Information sourced from Uniprot.org