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> Alpha B Crystallin (CRYAB) Rabbit Polyclonal Antibody [Clone ID: N/A]

Alpha B Crystallin (CRYAB) Rabbit Polyclonal Antibody [Clone ID: N/A]

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Cat# TA326430

Size : 200ul

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Alpha B Crystallin (CRYAB) Rabbit Polyclonal Antibody [Clone ID: N/A]

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SKU
TA326430
Rabbit polyclonal Alpha B Crystallin Antibody
Size:
200 ul
Conjugation:
Unconjugated
 

View other "Alpha B Crystallin or NM_001885" antibodies

Specifications
Product Data
Clone Name N/A
Application ICC/IF, IHC, WB
Recommended Dilution WB: 1:5000-10000
Reactivity Chicken, Cow, Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to human alpha B crystallin conjugated to KLH.
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide 
Concentration 1 mg/ml
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name crystallin alpha B
Database Link
Background The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27 . Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its phosphorylated state and may serve a structural control function and play a role in protein maintenance . In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA. Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases . Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions .
Synonyms CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2
Note Detects ~22kDa. Does not cross-react with aA-crystallin.
Reference Data
Protein Categories Cardiovascular diseases, Intracellular Proteins, Membrane Proteins, Nervous system Diseases
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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