AKT Kinase Inhibitor [842148-40-7]
Cat# NB-64-01441-1mg
Size : 1mg
Brand : Neo Biotech
Contact local distributor :
Phone : +1 850 650 7790
AKT Kinase Inhibitor
Catalog No. T10276 Copy Product Info
Purity: 99.13%
AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.
AKT Kinase Inhibitor
Copy Product InfoAKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.
Cas No. 842148-40-7
Select Batch
Purity:99.13%
Appearance:Solid
Color:White to Yellow
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner. |
| Targets&IC50 | Akt3:9 nM, GSK-3β:43-150 nM, Akt1:2 nM, Akt2:13 nM, Akt:2.5 µM |
| In vitro | METHODS: The proliferative effect of cells expressing Trop-2 was observed by silencing or inhibiting Akt with specific drugs. RESULTS The proliferative effect of cells expressing Trop-2 was significantly reduced in a dose-dependent manner.[1] |
| In vivo | METHODS: In an animal model, subcutaneously injected Trop-2-expressing tumors were treated with specific drugs that inhibit Akt activity. RESULTS Tumor growth was significantly reduced and Akt played a central functional role in mediating Trop-2-dependent growth stimulation.[1] |
| Molecular Weight | 357.37 |
| Formula | C16H19N7O3 |
| Cas No. | 842148-40-7 |
| Smiles | C(C)N1C=2C(=C(C#CCO)N=CC2OCCCN)N=C1C=3C(N)=NON3 |
| Relative Density. | 1.50 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 10 mg/mL (27.98 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.8 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
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