3-Isobutyl-1-methylxanthine [28822-58-4]

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Cat# 26445.02

Size : 500MG

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Phone : +1 850 650 7790

Brand : SERVA Electrophoresis

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Phone : +1 850 650 7790

(IBMX, 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione)
C₁₀H₁₄N₄O₂ • M_r 222.2 • CAS [28822-58-4]

3-Isobutyl-1-methylxanthine (IBMX) is one of the most potent and nonspecific inhibitors of cyclic nucleotide phosphodiesterases (cAMP- and cGMP-PDE). The increase in cAMP level because of phosphodiesterase inhibition by IBMX activates protein kinase A (PKA), leading to decreased proliferation, increased differentiation, and induction of apoptosis. The inhibitor induces calcium release from intracellular stores in sensory neurons.
IBMX has been used as a culture medium supplement for inducing adipogenic differentiation, for 3T3-L1 preadipocyte differentiation and in the differentiation of mesenchymal stem cells (MSC).
Soluble in ethanol.