1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE)

1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Synonyms:
9-Octadecenoic acid (9Z)-1,1'-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester;
9-Octadecenoic acid (9Z)-(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester; (R)-9-Octadecenoic acid (Z)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester; L-Olein 1,2-di-2-Aminoethyl Hydrogen Phosphate; L-2-Amino-ethanol Dihydrogen Phosphate Monoester with 1,2-Diolein; 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphorylethanolamine; Coatsome MC 8181; Coatsome ME 8181; DOPE; Dioleoyl-L-α-phosphatidylethanolamine; Dioleoylphosphatidylethanolamine; L-α-Dioleoylphosphatidylethanolamine

CAS No:
4004-05-1

Molecular Formula:
C₄₁H₇₈NO₈P

Molecular Weight:
744.03

Appearance:
White to off-white solid

Purity:
≥98%

Solubility:
Chloroform: 3mg/ml
Sparingly soluble in aqueous solutions

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.