α-Humulene (α-Caryophyllene) [6753-98-6]
Cat# 451988-1g
Size : 1g
Brand : US Biological
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451988 α-Humulene (α-Caryophyllene)
Grade
Highly PurifiedShipping Temp
RTStorage Temp
-20°Cα-Humulene is a sesquiterpene that has been found in C. sativa, C. indica, and hemp with diverse biological activities.1,2,3,4,5 It is lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19, 7.39, and 12.05 mg/ml, respectively).2 α-Humulene reduces growth of MCF-7 breast cancer cells by approximately 50% when used at a concentration of 32 mg/ml.3 It also reduces viability of Caco-2 cells in a concentration-dependent manner (IC50 = 24.4 mg/ml) but has no effect on viability of rat hepatocytes.4 In vivo, α-humulene (50 mg/kg) reduces histamine-induced paw edema in mice as well as carrageenan-induced TNF-α and IL-1β production and paw edema in mice and rats.5 It also reduces carrageenan-induced production of prostaglandin E2 (PGE2) and expression of inducible nitric oxide synthase (iNOS) and COX-2 in rats.
Synonyms:
(E,E,E)-2,6,6,9-tetramethyl-1,4,8-cycloundecatriene; α-Humulene; (1E,4E,8E)-2,6,6,9-Tetramethyl-1,4,8-cycloundecatriene; (±)-α-Humulene; α-Caryophyllene
CAS No:
6753-98-6
Molecular Formula:
C₁₅H₂₄
Molecular Weight:
204.35
Appearance:
Clear colorless oil
Purity:
≥95%
Solubility:
Chloroform (Slightly), Methanol (Slightly)
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.