Zebularine [3690-10-6]
Referência M3135-5mg
Tamanho : 5mg
Marca : AbMole Bioscience
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Telefone : +1 850 650 7790
All AbMole products are for research use only, cannot be used for human consumption.
NSC309132; 4-Deoxyuridine
Quality Control & Documentation
Biological Activity
Zebularine is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM.
Protocol (for reference only)
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| Animal models | male BALB/c nu/nu mice |
| Formulation | 0.45% saline |
| Dosages | 500 mg/kg, 1000 mg/kg |
| Administration | Intraperitoneal, oral |
Chemical Information
| Molecular Weight | 228.2 |
| Formula | C9H12N2O5 |
| CAS Number | 3690-10-6 |
| Solubility (25°C) | DMSO 60 mg/mL Water 25 mg/mL |
| Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Patryk Krzeminski, et al. Zebularine-induced myeloma cell death is accompanied by decreased c-Myc expression
[2] C B Yoo, et al. Zebularine: a new drug for epigenetic therapy
[3] Mingtan Tang, et al. Zebularine suppressed gemcitabine-induced senescence and improved the cellular and plasma pharmacokinetics of gemcitabine, augmented by liposomal co-delivery