Umifenovir

Biological Activity

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro.

Chemical Information

Molecular Weight	477.41
Formula	C22H25BrN2O3S
CAS Number	131707-25-0
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Serap Şimşek-Yavuz et al. Turk J Med Sci. An update of anti-viral treatment of COVID-19

[2] Behnam Amani et al. Immun Inflamm Dis. Efficacy and safety of arbidol (umifenovir) in patients with COVID-19: A systematic review and meta-analysis

[3] Ilad Alavi Darazam et al. Int Immunopharmacol. Umifenovir in hospitalized moderate to severe COVID-19 patients: A randomized clinical trial

[4] I A Leneva et al. Ter Arkh. [Umifenovir and coronavirus infections: a review of research results and clinical practice]

[5] Marzieh Nojomi et al. BMC Infect Dis. Effect of Arbidol (Umifenovir) on COVID-19: a randomized controlled trial