Trimethylamine N-oxide [1184-78-7]

Biological Activity

Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.

Chemical Information

Molecular Weight	75.11
Formula	C3H9NO
CAS Number	1184-78-7
Solubility (25°C)	Water 90 mg/mL DMSO 90 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Siyu He, et al. Cardiovasc Toxicol. Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases

[2] Kunpeng Wu, et al. Blood. The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

[3] Yingqian Zhu, et al. APMIS. Gut microbiota in atherosclerosis: focus on trimethylamine N-oxide

[4] Sifan Chen, et al. Cell Metab. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

[5] Steven H Zeisel, et al. Annu Rev Nutr. Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease