Tamanho : 50mg
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Synonyms: Substance P (7-11) acetate (51165-05-0 free base)
| Description | Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research. |
| In vitro | Substance P (7-11) acetate at concentrations greater than 1μM can promote the production of prostaglandin E₂ (PGE₂) and collagenase. Fluorescent dye Fura-2 detection revealed that the substance capable of increasing intracellular calcium concentration is Substance P (7-11), whereas intact SP, SP-(1-4), SP-(1-6), SP-(8-11) or SP-(9-11), as well as tachykinin family members neurokinin A (NKA) and neurokinin B (NKB), failed to induce the aforementioned intracellular calcium elevation effect. Additionally, the maximum change in intracellular calcium concentration induced by 10μM Substance P (7-11) was 140±30nM [1]. |
| Synonyms | Substance P (7-11) acetate (51165-05-0 free base) |
| Molecular Weight | 612.79 (free base) |
| Formula | C31H44N6O5S.xC2H4O2 |
| Smiles | N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC2=CC=CC=C2)=O.CC(O)=O |
| Sequence | Phe-Phe-Gly-Leu-Met-NH₂ |
| Sequence Short | FFGLM |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 1.5 mg/mL, when pH is adjusted to 2 with HCl. Sonication is recommended. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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