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> Streptavidin [9013-20-1]

Streptavidin [9013-20-1]

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Referência HY-P3152-10mg

Tamanho : 10mg

Marca : MedChemExpress

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Description

Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ~0.01 pM[1]. Streptavidin has an immunosuppressive role[2].
This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.

In Vitro

Streptavidin (2-200 μg/mL) significantly suppresses the proliferation of Lewis T cells to WF by 76%-83% compared with untreated responders[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Streptavidin Related Antibodies

Cell Viability Assay[1]

Cell Line: Lewis T cells
Concentration: 2-200 μg/mL
Incubation Time:
Result: Inhibited the proliferation of Lewis T cells to WF stimulators by 76%-83% compared with untreated responders, lower concentrations of 0.1 and 0.2 μg/mL did not significantly inhibit T-cell proliferation.
In Vivo

Streptavidin (8-80 mg/kg) treatment is effective in prolonging rat cardiac allografts in the high-responder WF-to-Lewis combination[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[2]
Dosage: 8, 12, 20, 40, 60, or 80 mg/kg
Administration: Administered IP for 5 consecutive days after transplantation was combined with a single dose of 0.5 mL antilymphocyte serum (ALS) on day 0
Result: Prolonged cardiac allograft survival from MST of 7.3±0.5 and 8.4±0.5 days in naive and ALS-treated controls, respectively, to 15±1, 20±3, 16±3, 17±3, and 23±2 days, respectively.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Streptavidin]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

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