Sodium Oleate

Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue. It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10ug/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5uM, similar to arachidonic acid. Oleic acid (60uM) induces release of intracellular calcium in human platelets. In vivo, oleic acid increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).

Synonyms:
Oleic acidsodium salt; cis-9-Octadecenoic acid sodium salt

CAS No:
143-19-1

Molecular Formula:
C18H33NaO2

Molecular Weight:
304.45

Appearance:
White to light yellow powder to crystal

Purity:
≥97% (Titration)

Loss on Drying:
≤3%

Component (Oleic Acid):
≥85%

Melting Point:
235°C

Solubility:
Water; Ethanol: 1mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5mg/ml

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Light Sensitive, Air Sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.